1. Overwhelming Stress: Life science Ph.D. students often face immense pressure due to the demanding nature of their research. The need to produce original, publishable results can lead to long hours in the lab, creating a stressful environment that can take a toll on mental health. This stress is compounded by the high expectations from supervisors and the academic community.

2. Inadequate Supervisory Support: The relationship between Ph.D. students and their supervisors is critical. Inadequate supervisory support can significantly impact a student’s progress and well-being. Issues such as lack of guidance, unrealistic expectations, and poor communication can lead to feelings of isolation and frustration (Schmidt & Hansson, 2018).

3. Financial Pressures: Securing funding is a common challenge for Ph.D. students. Many life science researchers rely on scholarships, grants, or part-time jobs to finance their studies. Financial instability can cause significant stress, affecting their ability to focus on their research and academic responsibilities (Stubb et al., 2011).

4. Work-Life Balance: Balancing the demands of a Ph.D. program with personal life is a constant struggle. The intense workload can lead to neglect of personal relationships and self-care, contributing to burnout and decreased life satisfaction. This imbalance is particularly pronounced in life sciences, where laboratory work often requires irregular hours.

5. Career Uncertainty: The path after a Ph.D. can be unclear for many students. The competitive nature of academic job markets and the limited availability of tenure-track positions add to the anxiety. Life science students may also face challenges in transitioning to industry roles, where their skills and experience may not be directly transferable (Devine & Hunter, 2017).

Psychological Responses and Happiness Index

Before Ph.D.: Before starting their Ph.D., aspirants typically exhibit high levels of motivation and enthusiasm. The excitement of embarking on a significant academic journey and the potential for groundbreaking research fuel their initial optimism (Juniper et al., 2012).

During Ph.D.: As students progress through their Ph.D., the initial enthusiasm often wanes. The combination of intense academic pressure, isolation, and uncertainty about future career prospects leads to decreased happiness and increased psychological distress. The mid-Ph.D. phase is particularly challenging, as students often face the highest workload and the most significant research obstacles (Schmidt & Hansson, 2018).

After Ph.D.: Post-Ph.D., many researchers experience a mix of relief and continued anxiety. While completing the Ph.D. provides a sense of accomplishment, the transition to the next career stage can be stressful. Job market challenges and the uncertainty of securing a desirable position contribute to ongoing stress, although the overall psychological distress may decrease compared to the Ph.D. period (Devine & Hunter, 2017).